Partnership

Engineering smart medicines by RNA design technology

Our value

01
Cell-specific
miRNA identification

Validated “active” miRNA screening platform

We have established screening platform for all known 2,650 miRNAs.

02
miRNA-based
gene circuit engineering

Multiple choice of miRNA genetic circuit

type: OFF switch, ON switch
Structure: mono sequence, tandem sequence
03
Application
& Test

Multiple choice of construct application

Synthetic mRNA construct

Applicable to gene therapy and genome editing (CRISPR-Cas9) by virus vector

Applications of RNA Switches

Through the cell-specific expression control by RNA switch, we aim to achieve the following;
Reduction of a number of required doses, diversification of routes of administration
Reduction of side-effects → Maximization of drug effectiveness
Development of novel therapeutic avenues
We are actively looking for partnerships in the following areas;
mRNA-based gene therapy
Design and development of mRNA-based drugs using RNA Switch technology
Cell therapy
Development of Switches that regulate the expression of transcription factors required for cell differentiation
Virus-based Gene Therapy
Design DNA sequences coding RNA Switches for improvement of specificity of partner’s virus modality
miRNA-based drug development
Identify miRNAs that could be viable therapeutic targets
In vitro / ex vivo
✓ Regenerative medicine
✓ CAR therapy

Cell Purification

Elimination of non-target cell

Cell Differentiation

Control of transcriptional
factor expression

Cell Regulation

Eliminate oncogenic
transplanted cells
In vivo (DNA-based)
✓ Oncolytic virus
✓ Gene therapy and genome editing by virus vector

Cell-specific Expression

Context-dependent expression control
(combination with serotype and promoter)

Dose-specific Expression

Keep transgene expression at defined level
In vitro / ex vivo
✓ Gene therapy and genome editing by mRNA

Cell-specific Expression

Context-dependent expression control
(combination with LNP)

Dose-specific Expression

Keep transgene expression at defined level
Category Application example Overview

In vitro / ex vivo

✓ Regenerative medicine
✓ CAR therapy
Cell Purification
Elimination of non-target cell
Cell Differentiatio
Control of transcriptional factor expression
Cell Regulation
Eliminate oncogenic transplanted cells

In vivo (DNA-based)

✓ Oncolytic virus
✓ Gene therapy and genome editing
by virus vector
Cell-specific
Expression
Context-dependent expression control
(combination with serotype and promoter)
Dose-specific Expression
Keep transgene expression at defined level

In vitro / ex vivo

✓ Gene therapy and genome editing by mRNA
Cell-specific
Expression
Context-dependent expression control
(combination with LNP)
Dose-specific Expression
Keep transgene expression at defined level